1 | P. S. Kumaraswamy Raja | 26. Jan. 1950 | 9. Apr. 1952 | INC |
2 | C. Rajagopalachari | 10. Apr. 1952 | 13. Apr. 1954 | INC |
3 | K. Kamaraj | 13. Apr. 1954 | 31. Mar. 1957 | INC |
4 | K. Kamaraj | 13. Apr. 1957 | 1. Mar. 1962 | INC |
5 | K. Kamaraj | 15. Mar. 1962 | 2. Oct. 1963 | INC |
6 | M. Bakthavatsalam | 2. Oct. 1963 | 6. Mar. 1967 | INC |
7 | C. N. Annadurai | 6. Mar. 1967 | 14. Jan. 1969 | DMK |
8 | C. N. Annadurai | 14. Jan. 1969 | 3. Feb. 1969 | DMK |
9 | V.R. Nedunchezhiyan (acting) | 3. Feb. 1969 | 10. Feb. 1969 | DMK |
10 | M. Karunanidhi | 10. Feb. 1969 | 4. Jan. 1971 | DMK |
11 | M. Karunanidhi | 15. Mar. 1971 | 31. Jan. 1976 | DMK |
| President's rule | 31. Jan. 1976 | 30. Jun. 1977 | |
12 | M. G. Ramachandran | 30. Jun. 1977 | 17. Feb. 1980 | AIADMK |
| President's rule | 17. Feb. 1980 | 9. Jun. 1980 | |
13 | M. G. Ramachandran | 9. Jun. 1980 | 15. Nov. 1984 | AIADMK |
14 | M. G. Ramachandran | 10. Feb. 1985 | 24. Dec. 1987 | AIADMK |
15 | V.R. Nedunchezhiyan (acting) | 24. Dec. 1987 | 7. Jan. 1988 | AIADMK |
16 | Janaki Ramachandran | 7. Jan. 1988 | 30. Jan. 1988 | AIADMK |
| President's rule | 30. Jan. 1988 | 27. Jan. 1989 | |
17 | M. Karunanidhi | 27. Jan. 1989 | 30. Jan. 1991 | DMK |
| President's rule | 30. Jan. 1991 | 24. Jun. 1991 | |
18 | J. Jayalalithaa | 24. Jun. 1991 | 12. May. 1996 | AIADMK |
19 | M. Karunanidhi | 13. May. 1996 | 13. May. 2001 | DMK |
20 | J. Jayalalithaa | 14. May. 2001 | 21. Sep. 2001 | AIADMK |
21 | O. Panneerselvam | 21. Sep. 2001 | 1. Mar. 2002 | AIADMK |
22 | J. Jayalalithaa | 2. Mar. 2002 | 12. May. 2006 | AIADMK |
23 | M. Karunanidhi | 13. May. 2006 | 15. May. 2011 | |
24 | J. Jayalalithaa | 16. May. 2011 | - | AIADMK |
24 | O Panneerselvam | 29th Sep 2014 | May 23, 2015 | AIADMK |
25 | J. Jayalalithaa | May 23, 2015 | Present | AIADMK |